Improved pharmacokinetics of mercaptopurine afforded by a thermally robust hemihydrate.
نویسندگان
چکیده
Structural and thermal data were obtained for a novel hemihydrate of 6-mercaptopurine. The hemihydrate shows increased solubility and bioavailability when compared to the monohydrate form, better stability against conversion in aqueous media than the anhydrate form, and a dehydration temperature of 240 °C, the highest of any known hydrate crystal.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 52 30 شماره
صفحات -
تاریخ انتشار 2016